Recent updates in the role of diffusion weightedMRI indiagnosis of cervical cancer

Abstract

Carcinoma oftheuterine cervix is the third most frequentlydiagnosedmalignancyinwomenworldwide.

Thepurposeofthisstudy istoevaluatetheroleof (MRI-DWI) in the diagnosis of cancer cervix in comparisonto(MRI-DCE).

Inthisstudy,pelvic MRIwithcontrastanddiffusion weredonefor30femalepatientsinwhom cervical carcinomaweresuspectedeitherclinicallyorbyTVUS& for 30femalepatientsasa control groupwhere pelvic MRI were done forotherpelvicdiseases.

By (DCE-MRI), 29cases were diagnosed as malignant cervical lesions &1 case was diagnosed as benign lesion,The(DWI-MRI)also hadthe sameresults whileby pathologicalexaminationrevealed28caseswere diagnosedasmalignant cervical lesions&2caseswas diagnosedasbenignlesion.

Thenwe comparedconventional(DW–MRI)and DCE-MRI images to pathological diagnosis to detect differencesinsensitivity,specificity,PPV, NPV.

Eachof the(DW–MRI)and(DCE-MRI) sequences when addedto the non-contrast MRI sequences in the

estimationofcancercervixhadelicitedthesamesensitivity value,specificityandaccuracy.

(DW–MRI)revealedSensitivity:96.68%, specificity:

93.33%,accuracy:94.9%,PPV:93.5%.

(ADC-MRI) revealedSensitivity: 86.67%, specificity:93.33%,accuracy: 87.8%,PPV:92.9%.

TheADCmapwasgenerated, and then automatically calculated on theworkstation togetameanADCvalue (0.003).

ThemeanADCvaluesformalignantlesionswere

(832.41±494.32SD).

WhilethemeanADCvalueinthecontrolgroupis

(1725.11±1506.72).

ADC value of(0.003)isacutoff between normal cervical tissue&malignant cervical lesion by sensitivity 86.67%andspecificity93.33%.

Asaresult, malignantcervical tumorsdueto their hypercellular nature showrestriction of diffusion,unlike mostbenigntumors.Soit impliesanoninvasive technique whichcanbe usedespeciallyif contrastintake isavoidedas inpregnancy.