Inhibin- B Hormone as a Predictor of Poor Ovarian Response
Amira Mansour Elsayed Ismail;
Abstract
Ovarian response is defined as the quantitative and qualitative endocrine and follicular reaction of the ovaries toastimuluswhileovarianreservereferstothe quantitation of residual pool of primordial follicles in the ovary and represents the reproductive age of the women (Kamini Rao et al., 2013).
During an Assisted Reproductive Technology (ART) cycle, ovarian responsiveness to gonadotropins is crucial for a successful clinical outcome. The quantity of embryos available for transfer and freezing is ultimately related to thenumberoffolliclesthatdevelopduringART stimulation (Arnot et al., 1995).
The evaluation of ovarian reserve has been and still substantial clinical research (Buckman et al., 2001).
The assessment of ovarian reserve isvaluable for determining stimulation protocols and predicting ART outcome. The concept of diminished ovarian reserve has gained general acceptance in infertility medicine. Correct identification of patients who are at risk for poor response can help physicians to individualize counselingand permit thepatients todecide whether toundergo ademanding infertilitytreatment.Accurateassessmentofovarianresponse potential before the patient enters an IVF program is,therefore, of pivotal importance (Jenkins et al., 1991).
Thelimitedpredictivevalueofagealonein estimating fecundity rates and response to the exogenous stimulation lead to evaluation of other parameters (Faddy and Gosden, 1996).
The aim of this study was to evaluate the accuracy Inhibin B hormone as a predictor of poor ovarian responder patients scheduled for ICSI.
This prospective study included 77 patients undergoing ICSI treatment in the assisted reproductive unit in Ain Shams Maternity Hospital. All women included in the study aged between 20-40 years With mean duration of infertility of 6 years. The study elicited the basal hormonal profile, AFC, number of HMG ampoules and number of oocytes retrieved of the whole studied cases. Patients included in the study were divided retrospectively into two groupsaccordingtothenumberofretrievedoocytes: normal responders with four or more retrieved oocytes and poor responders with less than four retrieved oocytes.
During an Assisted Reproductive Technology (ART) cycle, ovarian responsiveness to gonadotropins is crucial for a successful clinical outcome. The quantity of embryos available for transfer and freezing is ultimately related to thenumberoffolliclesthatdevelopduringART stimulation (Arnot et al., 1995).
The evaluation of ovarian reserve has been and still substantial clinical research (Buckman et al., 2001).
The assessment of ovarian reserve isvaluable for determining stimulation protocols and predicting ART outcome. The concept of diminished ovarian reserve has gained general acceptance in infertility medicine. Correct identification of patients who are at risk for poor response can help physicians to individualize counselingand permit thepatients todecide whether toundergo ademanding infertilitytreatment.Accurateassessmentofovarianresponse potential before the patient enters an IVF program is,therefore, of pivotal importance (Jenkins et al., 1991).
Thelimitedpredictivevalueofagealonein estimating fecundity rates and response to the exogenous stimulation lead to evaluation of other parameters (Faddy and Gosden, 1996).
The aim of this study was to evaluate the accuracy Inhibin B hormone as a predictor of poor ovarian responder patients scheduled for ICSI.
This prospective study included 77 patients undergoing ICSI treatment in the assisted reproductive unit in Ain Shams Maternity Hospital. All women included in the study aged between 20-40 years With mean duration of infertility of 6 years. The study elicited the basal hormonal profile, AFC, number of HMG ampoules and number of oocytes retrieved of the whole studied cases. Patients included in the study were divided retrospectively into two groupsaccordingtothenumberofretrievedoocytes: normal responders with four or more retrieved oocytes and poor responders with less than four retrieved oocytes.
Other data
| Title | Inhibin- B Hormone as a Predictor of Poor Ovarian Response | Other Titles | هرمون الانهيبين- ب كمتنبىء لضعف إستجابة المبيض | Authors | Amira Mansour Elsayed Ismail | Issue Date | 2017 |
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