MOLECULAR BASIS Of ACUTE LEUKEMIA AND ITS APPLICATIONS
Mahira Ismaill Wagih El-Mougy;
Abstract
Acute leukemia is a malignant disease characterized by a clonal porliferation of malignant blasts in the marrow and impaired production of normal blood cells. It is broadly subdivided into myeloid and lymphoblastic categories based on the cell of origin. For classification ofleukemic blast cells in acute leukemia; morphology, cytochemistry, immunopheno typing and molecular cytogenetic studies are required.
For understanding the underlying molecular basis of acute leukemia, it is necessary to clarifY the basic genetic principles of the cell, its regulation, the major events that take place in the cell cycle and the various affecting factors that drive the cell to either survival or death.
Genes are the units of inheritance, consist of DNA molecules which store the information in the form of nucleotide sequences, that are transmitted by replication to daughter cells, and express it by directing the incorporation of amino-acids into proteins. The human genome is made up of3 x 10 9 base pairs of DNA packaged into 23 pairs of chromosomes. Abnormalities of chromosomes may be either numerical or structural that may lead to an abnormal fusion gene which is considered as the underlying cause of many neoplasms. These moleculo cytogenetic abnormalities have been used for diagnosis, classification, choice of, or approach to therapy as well as prognosis of the disease.
For understanding the underlying molecular basis of acute leukemia, it is necessary to clarifY the basic genetic principles of the cell, its regulation, the major events that take place in the cell cycle and the various affecting factors that drive the cell to either survival or death.
Genes are the units of inheritance, consist of DNA molecules which store the information in the form of nucleotide sequences, that are transmitted by replication to daughter cells, and express it by directing the incorporation of amino-acids into proteins. The human genome is made up of3 x 10 9 base pairs of DNA packaged into 23 pairs of chromosomes. Abnormalities of chromosomes may be either numerical or structural that may lead to an abnormal fusion gene which is considered as the underlying cause of many neoplasms. These moleculo cytogenetic abnormalities have been used for diagnosis, classification, choice of, or approach to therapy as well as prognosis of the disease.
Other data
| Title | MOLECULAR BASIS Of ACUTE LEUKEMIA AND ITS APPLICATIONS | Other Titles | الأسس الجزيئية وتطبيقاتها فى سرطان الدم | Authors | Mahira Ismaill Wagih El-Mougy | Issue Date | 2001 |
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