Correlation between the biofilm formation and the presence of extended spectrum β - lactamase (ESBL) bla PER-1 gene in multiple drug resistant clinical isolates of Acinetobacter baumannii

Abstract

A. baumannii has emerged as an important and problematic human pathogen as it is the causative agent of several types of healthcare-associated infections including pneumonia, meningitis, wound infection, septicaemia and urinary tract infection especially if these infections associated with medical devices. As a result of both intrinsic and acquired mechanisms, multidrug-resistant A. baumannii has been reported worldwide and is now recognized as one of the most difficult healthcare-associated infections to control and to treat .MDR A. baumannii is not a new or emerging phenomenon, but A. baumannii has always been an organism inherently resistant to multiple antibiotics . The potential ability of A. baumannii to form biofilms might also explain its outstanding antibiotic resistance, survival properties and increased virulence. Study of microbial biofilms has received significant attention over the past decades.