Studying The Use Of Magnesium Sulphate For Brain Protection In Traumatic Head Injury
Tamer Mousaad Abdel-Hamid Gamal Eldin;
Abstract
The current study describes the significance of supplemental magnesium for brain protection after traumatic brain injury .In this study, 300 adult patients admitted to a Trauma ICU in Kasr El-eini hospital - Cairo university between October , 2008, and April 2010 ,with mild , moderate or severe traumatic brain injury were randomly assigned one of two doses of magnesium or placebo within 8 h of injury and continuing for 5 days. Magnesium doses were targeted to achieve serum magnesium range of 4•0 mEq/L. The outcome was a composite of mortality, seizures, time of stay in hospital and functional measures assessed up to 6 months after injury. Data are presented as mean (SD) parametric and non parametric versions of ANOVA test will be used for analysis of continuous and discrete data, as appropriate, with past tests done if significance is detected.
P value < 0.05 will considered statistically significant.
The study results were , At the magnesium group , the toal mortality rate for the magnesium cases was significantly less than that for placebo ( p value = 0.039) and also in the moderate GCS cases (p value =0.033 ).
However there were no significant differences in both mild (p value =0.051 ) and severe cases (p value =0.067 )
Early seizures and late seizures were generally less in all the magnesium groups ( p value = 0.040) , mild( p value = 0.041) , moderate( p value = 0.033) and severe ( p value = 0.046) .
Glasgow outcome scale-extended scores yielded significant results in the moderate group( p value = 0.033),and no significance in mild case ( p value = 0.067)or severe cases ( p value = 0.086) .
Regarding the time of stay in hospital and ICU there was significant difference between magnesium and placebo groups after 4 weeks of hospital stay (P=0.037) .
The conclusion was that “Parenteral magnesium sulphate by intravenous infusion within the first 8 hours after bolus dose in head trauma for the first 5 days trying to keep serum level of magnesium around 4 mEq/L appears to improve survival , reduce early and late seizures , shorten period of hospital stay in all patients with traumatic head injury , and is associated with better favorable outcome and less disability at 6 months in patients with GCS 9-12 ,without any apparent significant adverse effects”.
P value < 0.05 will considered statistically significant.
The study results were , At the magnesium group , the toal mortality rate for the magnesium cases was significantly less than that for placebo ( p value = 0.039) and also in the moderate GCS cases (p value =0.033 ).
However there were no significant differences in both mild (p value =0.051 ) and severe cases (p value =0.067 )
Early seizures and late seizures were generally less in all the magnesium groups ( p value = 0.040) , mild( p value = 0.041) , moderate( p value = 0.033) and severe ( p value = 0.046) .
Glasgow outcome scale-extended scores yielded significant results in the moderate group( p value = 0.033),and no significance in mild case ( p value = 0.067)or severe cases ( p value = 0.086) .
Regarding the time of stay in hospital and ICU there was significant difference between magnesium and placebo groups after 4 weeks of hospital stay (P=0.037) .
The conclusion was that “Parenteral magnesium sulphate by intravenous infusion within the first 8 hours after bolus dose in head trauma for the first 5 days trying to keep serum level of magnesium around 4 mEq/L appears to improve survival , reduce early and late seizures , shorten period of hospital stay in all patients with traumatic head injury , and is associated with better favorable outcome and less disability at 6 months in patients with GCS 9-12 ,without any apparent significant adverse effects”.
Other data
| Title | Studying The Use Of Magnesium Sulphate For Brain Protection In Traumatic Head Injury | Authors | Tamer Mousaad Abdel-Hamid Gamal Eldin | Issue Date | 2011 |
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