EFFECT OF MAGNESIUM SULPHATE ON POSTOPERATIVE ANALGESIA IN ELECTIVE CAESARIAN SECTION
Wessam Zaher Mohamed Abd-Elmohsen Selima;
Abstract
T
he safety and efficacy of regional anaesthesia for patients
undergoing caesarean section is established, but one limitation of spinal anaesthesia is the relatively short duration of postoperative analgesia. Postoperative pain is associated with neuroendocrine responses, catecholamine release and increased morbidity. In addition, effective pain relief facilitates early ambulation and care of the newbom (Malleeswaran et al., 2010).
Magnesium inhibits calcium entry into the cell Via a
noncompetitive blockade of the N-methyl-d-aspartate (NMDA)
receptor. Magnesium and the NMDA receptor are thought to be
involved in the modulation of pain. Magnesium is also a physiological calcium antagonist at different voltage-gated channels (which may be important in the mechanisms of antinociception (Christopher et al., 2007).
The characteristics of magnesium (having an anesthetic- and analgesic-sparing effect) nenable anesthesiologists to reduce the use of anesthetics during surgery and the use of analgesics after surgery. Magnesium sulfate has a high therapeutic index and cost-effectiveness. Considering these diverse characteristics useful for anesthesia, appropriate use of magnesium sulfate would improve surgical outcome
and patients' satisfaction (Do, 2013).
he safety and efficacy of regional anaesthesia for patients
undergoing caesarean section is established, but one limitation of spinal anaesthesia is the relatively short duration of postoperative analgesia. Postoperative pain is associated with neuroendocrine responses, catecholamine release and increased morbidity. In addition, effective pain relief facilitates early ambulation and care of the newbom (Malleeswaran et al., 2010).
Magnesium inhibits calcium entry into the cell Via a
noncompetitive blockade of the N-methyl-d-aspartate (NMDA)
receptor. Magnesium and the NMDA receptor are thought to be
involved in the modulation of pain. Magnesium is also a physiological calcium antagonist at different voltage-gated channels (which may be important in the mechanisms of antinociception (Christopher et al., 2007).
The characteristics of magnesium (having an anesthetic- and analgesic-sparing effect) nenable anesthesiologists to reduce the use of anesthetics during surgery and the use of analgesics after surgery. Magnesium sulfate has a high therapeutic index and cost-effectiveness. Considering these diverse characteristics useful for anesthesia, appropriate use of magnesium sulfate would improve surgical outcome
and patients' satisfaction (Do, 2013).
Other data
| Title | EFFECT OF MAGNESIUM SULPHATE ON POSTOPERATIVE ANALGESIA IN ELECTIVE CAESARIAN SECTION | Other Titles | تأثير سلفات الماغنسيوم علي تسكين الألام بعد العمليات في الولادات القيصرية المنتخبة | Authors | Wessam Zaher Mohamed Abd-Elmohsen Selima | Issue Date | 2014 |
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