Adrenomedullin As A Marker In Neonatal Sepsis

Abstract

Sepsis neonatorum is a maJor cause of morbidity and mortality in neonates. Infection in the newborn may present with non-specific often subtle clinical findings in both term and pre term infants and in both early and late onset sepsis. An accurate test for the diagnosis of neonatal sepsis in a group of newborns initially suspected of sepsis needs a high sensitivity, because all true septic patients have to be identified. In this study, ADM and TNF-a were estimated as an

indicator of sepsis in 25 newborn infants with symptoms and signs of neonatal sepsis, I6 of them were males and 9 were females. Their ages ranged between I-27 days (Mean I 1.76 ± 7.27). Mean sepsis score was (9.56 ± 1.99) and all were CRP

+ve.

ADM plasma level and TNF-a serum level were significantly high in newborns with sepsis compared with the