The Association Between ANA, Anti Ds DNA and Polycystic Ovary Syndrome

Abstract

SUMMARY P COS is the most common endocrinopathy in adult women, and is emerging as common cause of menstrual disturbances in adolescent population. Prevelance of PCOS could differ among different population. However prevelance of PCOS seems to increase rapidly owing to the world- wide epidemic of obesity related to unhealthy dietary habits and physical inactivity. The aetiology of PCOS remains uncertain but there is increasing evidence for auto immune disease so screening for auto antibodies in PCOS women may help in diagnosis of PCOS. It has been postulated that all women with PCOS may have insulin resistance. Insulin resistance has been demonstrated to be greater in both lean and obese women with PCOS compared with non-PCOS women of comparable weight, suggesting that the defect is intrinsic to this disorder. To establish the diagnosis of PCOS, the goal is to confirm ovarian hyperandrogenism, and exclude other causes of hyperandrogenism and menstrual dysfunction such as adrenal or ovarian tumours, non classical adrenal hyperplasia, cushing's syndrome, hyperprolactinemia, and thyroid disease. The recent PCOS consensus meeting held in Rotte