Evaluation of differential leucocytes ratio as a predictor for disease activity in patients with ulcerative colitis

Abstract

Ulcerative colitis is a chronic, idiopathic disease caused by a dysregulated immune response to host intestinal microflora and marked by recurrent episodes of inflammation in the gastrointestinal tract (Stroberet al., 2007). Diagnosis of UC is based on a combination of clinical history and examination, blood parameters, radiology and the gold standard to establish diagnosis remains the endoscopy and histopathology (Joseph et al., 2014). In order to avoid invasive investigations, several noninvasive markers have been evaluated for their capacity to distinguish between functional and organic inflammatory gastrointestinal disease. Neutrophils to lymphocyte NLR and lymphocyte to monocyte LMR ratios can be sensitive markers for the detection of bowel inflammation. This current study aimed to clarify the role of differential leucocyte ratio, Neutrophils to lymphocyte NLR ratio and lymphocyte to monocyte LMR as a simple, easy and available predictor for disease activity in patients with ulcerative colitis. The present study was conducted on 40 patients with UC (20 active UC and 20 inactive UC) versus 20 healthy individuals as controls.