"Synthesis of Novel Hybrid Steroidal Derivatives and Evaluation of their Nanoparticles as Anticancer Agents

Abstract

Cancer is a multicellular disease that can arise from any cell types and organs with a multi-factorial etiology. In 2008, World health organization (WHO) considered it as the leading cause of death worldwide, accounting for 7.6 million deaths (around 13% of all deaths). Anticancer agents consisting of hybrid molecules are used to improve effectiveness and diminish drug resistance. The current study aimed to introduce newly synthesized heterocyclic steroids of promising anticancer effects which are loaded in polyethylene glycol (PEG( based nanoparticles form. In this study several heterocyclic steroids (I-IX) were synthesized via multicomponant reactions (MCRs) using 5α-cholestan-3-one as starting material. The analytical and spectral data (IR, 1HNMR, 13CNMR, and mass spectrum) of all new compounds are compatible with the proposed structures.