Recent Advances In Management Of Acute Leukemia In Children
Iman Nasr Mahrous;
Abstract
Leukemia is the most common Childhood cancers; leukemia accounts for about one third of pediatric malignancies. Acute lymphoblastic leukemia (ALL) represents approximately 75% of all cases in children, and has a peak incidence at age of 4 years. Acute Myelogenous leukemia (AML) accounts for approximately 20% of leukemia, with a stable incidence from birth through age of 10 and increase slightly during the teenage years.
The cause of leukemia is unknown in the majority of patients. Several factors, however, associated with the development of leukemia. These factors are:
Environmental factors: Ionizing radiation and certain toxic chemical have a major role in development of leukemia.
Genetics factors: are presumed to play a significant role in the cause of acute leukemias. Evidence is based on several observations, including the association between various constitutional chromosomal abnormalities, the occurrence of familial leukemia, the high incidence in identical twins, and the demonstration of karyotypic abnormalities in leukemia cells.
Viral infection: The Epstein-Barr virus (EBV) has been linked to cases of endemic Burkitt's lymphoma and the L3 subtype of ALL.
Immunodeficiency: Several Immunodeficiency states have an associated increased risk for lymphoma and leukemia.
The cause of leukemia is unknown in the majority of patients. Several factors, however, associated with the development of leukemia. These factors are:
Environmental factors: Ionizing radiation and certain toxic chemical have a major role in development of leukemia.
Genetics factors: are presumed to play a significant role in the cause of acute leukemias. Evidence is based on several observations, including the association between various constitutional chromosomal abnormalities, the occurrence of familial leukemia, the high incidence in identical twins, and the demonstration of karyotypic abnormalities in leukemia cells.
Viral infection: The Epstein-Barr virus (EBV) has been linked to cases of endemic Burkitt's lymphoma and the L3 subtype of ALL.
Immunodeficiency: Several Immunodeficiency states have an associated increased risk for lymphoma and leukemia.
Other data
| Title | Recent Advances In Management Of Acute Leukemia In Children | Other Titles | احدث اساليب تشخيص وعلاج سرطان الدم الحاد فى الاطفال | Authors | Iman Nasr Mahrous | Issue Date | 2000 |
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