The Use of Simvastatin Gel with Perforated Resorbable Membranes in the Treatment of Intrabony Defects in Chronic Periodontitis Patients (Clinical and Biochemical Study)

Abstract

The hopeful goal of periodontal therapy is regeneration of the lost part of the periodontium on a previously diseased root surface. Currently, the major progress is being made to achieve this goal by utilizing various regenerative procedures such as bone grafting, guided tissue regeneration techniques and combination therapy. The present investigation was conducted to evaluate the clinical and radiographic outcome and simvastatin gingival crevicular fluid levels availability for 30 days following the use of simvastatin gel combined with a modified perforated resorbable membrane compared with simvastatin gel combined with a traditional cell occlusive resorbable membrane in cases with and without EDTA root surface etching for improving bone regeneration in intrabony defects in chronic periodontitis patients. The study was performed on forty patients having chronic periodontitis aged from 30 to 50 years with 40 intrabony defects divided into four groups. Group I in which 10 patients received open flap procedure and 1.2% simvastatin gel and covering the defect with resorbable collagen occlusive membrane. Group II in which 10 patients received open flap procedure and 1.2% simvastatin gel and covering the defect resorbable collagen modified perforated membrane. Group ΙIΙ in which 10 patients