Assessment of the effect of lyophilized Human Platelets Derived Growth Factors on Superficial Facial Wrinkles

Abstract

ging is a physiological process which affects all body organs but when it comes to skin aging it becomes a very distressing matter, because it affects all aspects of persons’ life. Skin aging occurs by combined mechanisms, intrinsic as hereditary factors or hormonal factors and extrinsic as UVR and smoking. The combination of these factors and others lead to the appearance of signs of aged skin clinically in the form of atrophy, laxity, sagging, dryness, dyspigmentation, telangiectasia and wrinkles. These distressing signs lead to increased research in the area of preventing and treating skin aging. Skin aging treatment has became a very important concern in the recent times, many lines of treatment are available for each sign of skin aging as botulinum toxin, fillers, mesotherapy, PRP, and skin resurfacing. The PRP stimulates the natural healing cascade and tissue regeneration through a ‘super physiologic’ release of platelet-derived factors directly at the site of treatment. These can result in up regulation of collagen synthesis, down regulation of collagen degradation, increase in angiogenesis and cell proliferation. Lyophilized human platelets derived growth factors (L-GF) are considered another simple method of growth factors preparation. It is prepared using platelets concentration derived from different donors. It is ubiquitously available and allows physicians to apply a defined amount of growth factors. To the best of our knowledge, previous studies didn’t investigate the role of L-GF for skin rejuvenation. Therefore, we aimed in the current study to assess the effect L-GF on superficial facial wrinkles. To achieve our goal, we included 20 patients between 30