IMMUNOEXPRESSION OF TENASCIN AND FIBRONECTIN IN ACNE VULGARIS
Gehan Mohammed Ragy Helal;
Abstract
Acne vulgaris is a chronic, self limited, inflammatory disease of the pilosebaceous units.
It is a polymorphic disorder which exhibits a senes of diverse lesions, comedones, papules, pustules, nodules, cysts and scars. The sites of primary involvement are located on the face, chest and back. Histopathologically, ductal hypercomification is one of the pathogenic features of acne vulgaris .
Tenascin and fibronectin are extracellular matrix glycoproteins which can interact with cells and alter their capacity to adhere migrate and proliferate. In contrast with fibronection, tenascin has a restricted distribution in normal skin, but is induced during epidermal proliferation and in wound healing.
The present study included 20 skin biopsies taken from the back of acne patients and 5 biopsies from apparently normal skin from non-acne patients as a control group. The diseased biopsies were divided into two groups, group I included 10 patients with non-inflamed acne lesions and Group II included 10 patients with inflamed acne lesions.
All tissue specimens were examined histopathologically using Hematoxylin and Eosin stains and immunohistochemically to detect tenascin and fibronectin expression.
It is a polymorphic disorder which exhibits a senes of diverse lesions, comedones, papules, pustules, nodules, cysts and scars. The sites of primary involvement are located on the face, chest and back. Histopathologically, ductal hypercomification is one of the pathogenic features of acne vulgaris .
Tenascin and fibronectin are extracellular matrix glycoproteins which can interact with cells and alter their capacity to adhere migrate and proliferate. In contrast with fibronection, tenascin has a restricted distribution in normal skin, but is induced during epidermal proliferation and in wound healing.
The present study included 20 skin biopsies taken from the back of acne patients and 5 biopsies from apparently normal skin from non-acne patients as a control group. The diseased biopsies were divided into two groups, group I included 10 patients with non-inflamed acne lesions and Group II included 10 patients with inflamed acne lesions.
All tissue specimens were examined histopathologically using Hematoxylin and Eosin stains and immunohistochemically to detect tenascin and fibronectin expression.
Other data
| Title | IMMUNOEXPRESSION OF TENASCIN AND FIBRONECTIN IN ACNE VULGARIS | Other Titles | دراسة الإنطباع المناعى للتيناسين والفيبرونيكتين فى مرض حب الشباب | Authors | Gehan Mohammed Ragy Helal | Issue Date | 2000 |
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