The Effect of Glucosamine on Nuclear Factor-kappa B Signaling Pathway in Oral Lichen Planus: A Clinical and Immunohistochemical Study
Radwa Ragheb Hussein Mohamed Farag;
Abstract
The present study was conducted on thirty patients suffering from erosive or atrophic OLP, to compare the clinical efficacy of combined oral GlcN and two topical corticosteroid regimens to that of topical corticosteroid alone in the treatment of symptomatic OLP and to determine the therapeutic mechanism by investigating the treatment effect on the expression of IKKα and IL-8 in OLP specimens.
Patients were randomly assigned in three equal groups to receive :combination of topical steroid (triamcinolone acetonide 0.1 %) four times per day and (glucosamine sulfate 500mg ) orally three times per day for eight weeks(Group I) or combination of topical steroid (triamcinolone acetonide 0.1%) two times per day and (glucosamine sulfate 500mg) orally three times per day for eight weeks ( Group II) or topical steroid (triamcinolone acetonide0.1%) alone four times per day for eight weeks (Group III)and followed up for another treatment free four weeks observational period. Photographs of the most severe lesion were taken (Marker lesion) in each patient and analyzed for Total Ulcerative Area (TUA), Total Atrophic Area (TAA), and Total White Area (TWA), patients were also assessed using clinical scores (CS) and visual analogue scale (VAS).
Punch biopsy specimens were taken in two occasions from each patient; at baseline and after the eight weeks treatment period. The total number of IKKα and area fraction of IL-8 were assessed in immune-stained sections.
The present study revealed that the three groups showed significant reduction in all parameters after treatment termination, However, Group I showed the least mean CS in all follow up visits and VAS in visits two, three and four in comparison to other groups although it was the highest at baseline also the group I and group II demonstrated initial significant reduction in VAS and TUA after the first two weeks, while this reduction was significant in the third group after the 4th week of treatment. Although the TUA in group I showed significant reduction at the end of the 1st week of
Patients were randomly assigned in three equal groups to receive :combination of topical steroid (triamcinolone acetonide 0.1 %) four times per day and (glucosamine sulfate 500mg ) orally three times per day for eight weeks(Group I) or combination of topical steroid (triamcinolone acetonide 0.1%) two times per day and (glucosamine sulfate 500mg) orally three times per day for eight weeks ( Group II) or topical steroid (triamcinolone acetonide0.1%) alone four times per day for eight weeks (Group III)and followed up for another treatment free four weeks observational period. Photographs of the most severe lesion were taken (Marker lesion) in each patient and analyzed for Total Ulcerative Area (TUA), Total Atrophic Area (TAA), and Total White Area (TWA), patients were also assessed using clinical scores (CS) and visual analogue scale (VAS).
Punch biopsy specimens were taken in two occasions from each patient; at baseline and after the eight weeks treatment period. The total number of IKKα and area fraction of IL-8 were assessed in immune-stained sections.
The present study revealed that the three groups showed significant reduction in all parameters after treatment termination, However, Group I showed the least mean CS in all follow up visits and VAS in visits two, three and four in comparison to other groups although it was the highest at baseline also the group I and group II demonstrated initial significant reduction in VAS and TUA after the first two weeks, while this reduction was significant in the third group after the 4th week of treatment. Although the TUA in group I showed significant reduction at the end of the 1st week of
Other data
| Title | The Effect of Glucosamine on Nuclear Factor-kappa B Signaling Pathway in Oral Lichen Planus: A Clinical and Immunohistochemical Study | Other Titles | تاثيرالجليكوزامينعلىمسارالمعاملالنوويكابا بفيآفةالحزازالفميالمنبسط: دراسةاكلينيكيةومناعيةهيستوكيميائية | Authors | Radwa Ragheb Hussein Mohamed Farag | Issue Date | 2016 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| G12900.pdf | 502.77 kB | Adobe PDF | View/Open |
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