Effect of Antiepileptic Drugs on Bone Metabolism in Pediatric Patients with Idiopathic Epilepsy
Wael Abd El-Halim Mohamed Hussein;
Abstract
SUMMARY
O
ur clinical trial study was conducted to investigate the effects of antiepileptic drugs on bone mineral density and bone turnover markers among children with idiopathic epilepsy.
Our study included 40 children with idiopathic epilepsy, their ages ranged from 6-12 years, they included 22 males and 18 females, and the mean duration of treatment with AEDs was 4.23 ± 1.15 years ranged from 3-8 years. Forty normal healthy children of the same age and sex served as controls.
All children were subjected to full history taking, complete clinical examination, Bone mineral density assessment by (DXA) scan and finally laboratory investigation by measuring levels of serum Ca, P, Alkaline phosphatase (ALP) and the bone resorption marker C-terminal telopeptide of type 1 collagen (CTX).
The results of our study showed that there was significant difference between patients and controls groups regarding bone mineral density (BMD) of lumbar spine being lower in patients compared to the controls.
Also, we found significant increase in bone formation and turnover markers in epileptic children where both of alkaline phosphatase and C-terminal telopeptide of type 1
O
ur clinical trial study was conducted to investigate the effects of antiepileptic drugs on bone mineral density and bone turnover markers among children with idiopathic epilepsy.
Our study included 40 children with idiopathic epilepsy, their ages ranged from 6-12 years, they included 22 males and 18 females, and the mean duration of treatment with AEDs was 4.23 ± 1.15 years ranged from 3-8 years. Forty normal healthy children of the same age and sex served as controls.
All children were subjected to full history taking, complete clinical examination, Bone mineral density assessment by (DXA) scan and finally laboratory investigation by measuring levels of serum Ca, P, Alkaline phosphatase (ALP) and the bone resorption marker C-terminal telopeptide of type 1 collagen (CTX).
The results of our study showed that there was significant difference between patients and controls groups regarding bone mineral density (BMD) of lumbar spine being lower in patients compared to the controls.
Also, we found significant increase in bone formation and turnover markers in epileptic children where both of alkaline phosphatase and C-terminal telopeptide of type 1
Other data
| Title | Effect of Antiepileptic Drugs on Bone Metabolism in Pediatric Patients with Idiopathic Epilepsy | Authors | Wael Abd El-Halim Mohamed Hussein | Issue Date | 2018 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.