VITAMIN D STATUS IN DIFFUSE LARGE B CELL LYMPHOMA (DLBCL) AT PRESENTATION
Dalia Mohammed Osman Mohamme;
Abstract
itamin D is a group of fat soluble pro hormone which was identified after the discovery of anti-rachitic effect of cod liver oil in the early part of 20th century. The vitamin found in cod liver was designated "D" following vitamin A, B, and C which has been discovered earlier (Wolpowitz et al., 2006). The Two major biologically inert precursors of vitamin D are vitamin D3 (colicalciferol) and vitamin D2 (ergocalciferol) (Vieth, 2004).
Vitamin D in addition to its role in calcium hemostasis and absorption is one of the most potent hormones for regulating cell growth. It was discovered that many cell types contain vitamin D receptors. These receptors can be activated by 1, 25 (OH) 2D, and induce differentiation into normally functioning cells, and inhibit proliferation, invasiveness, angiogenesis and metastatic potential. In tumor modules such as cancers of the lung (Young et al., 1995), colon (Evans et al., 2000), breast (Sundaramet al., 2003). Vitamin D played a role in activity against metastasis (Colston., 2008).
The protective relationship between sufficient vitamin D status and lower risk of cancer has been found in many studies. It has been reported that breast and colorectal cancer can be reduced by 50%with concentration of 25 dihydroxy vitamin D being >32mg/ml (Lappe et al., 2008). A similar study of colorectal cancer found that level of 34mg/ml 25 dihydroxy vitamin D can reduce the incidence by half and 46mg/ml can reduce the incidence by two thirds (Khosla et al., 2007).
The first study indicate that sunlight exposure may lower the risk of cancer was first made almost seven decates ago. Also Garland C and Garland F propose that vitamin D deficiency may contribute to a higher risk of colon cancer mortality since vitamin D formed in the skin through solar UVB Radiation. Moreover many studies revealed that there is increase risks of certain types of cancer in those who are vitamin D deficient, suggests that vitamin D deficiency may account for thousands of premature death from colon (Garland et al., 1980) Breast (Garland et al., 1990), ovarian (Lefkowitzet al., 1994) and prostate cancer (Schwartz et al., 1990).
Despite growing evidence for a relationship between vitamin D levels and solid tumor risk, farless is known about the relationship between vitamin D and the risk of hematologic malignancy. A pooled analysis of 10 studies found that higher levels of recreational sun exposure. which would be anticipated to increase vitamin D levels, was
Vitamin D in addition to its role in calcium hemostasis and absorption is one of the most potent hormones for regulating cell growth. It was discovered that many cell types contain vitamin D receptors. These receptors can be activated by 1, 25 (OH) 2D, and induce differentiation into normally functioning cells, and inhibit proliferation, invasiveness, angiogenesis and metastatic potential. In tumor modules such as cancers of the lung (Young et al., 1995), colon (Evans et al., 2000), breast (Sundaramet al., 2003). Vitamin D played a role in activity against metastasis (Colston., 2008).
The protective relationship between sufficient vitamin D status and lower risk of cancer has been found in many studies. It has been reported that breast and colorectal cancer can be reduced by 50%with concentration of 25 dihydroxy vitamin D being >32mg/ml (Lappe et al., 2008). A similar study of colorectal cancer found that level of 34mg/ml 25 dihydroxy vitamin D can reduce the incidence by half and 46mg/ml can reduce the incidence by two thirds (Khosla et al., 2007).
The first study indicate that sunlight exposure may lower the risk of cancer was first made almost seven decates ago. Also Garland C and Garland F propose that vitamin D deficiency may contribute to a higher risk of colon cancer mortality since vitamin D formed in the skin through solar UVB Radiation. Moreover many studies revealed that there is increase risks of certain types of cancer in those who are vitamin D deficient, suggests that vitamin D deficiency may account for thousands of premature death from colon (Garland et al., 1980) Breast (Garland et al., 1990), ovarian (Lefkowitzet al., 1994) and prostate cancer (Schwartz et al., 1990).
Despite growing evidence for a relationship between vitamin D levels and solid tumor risk, farless is known about the relationship between vitamin D and the risk of hematologic malignancy. A pooled analysis of 10 studies found that higher levels of recreational sun exposure. which would be anticipated to increase vitamin D levels, was
Other data
| Title | VITAMIN D STATUS IN DIFFUSE LARGE B CELL LYMPHOMA (DLBCL) AT PRESENTATION | Other Titles | حالة فيتامين د في المرضي المصابين بسرطان الخلايا الليمفاوية كبيرة الحجم من النوع ب عند بداية تشخيص المرض. | Authors | Dalia Mohammed Osman Mohamme | Issue Date | 2014 |
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