Comparison between the Efficacy of Collagen Biodegradable Matrix and Mitomycin C in Subscleral Trabeculectomy

Abstract

Trabeculectomy is still the optimum surgical intervention for treating cases with uncontrolled glaucoma worldwide. However, what leads to bleb failure is the fibrosis that occurs in the sub-conjunctival tissues and this in turn leads to decreasing the long-term success rate of trabeculectomy procedure. With the introduction of adjunctive anti-metabolites such as MMC, the recorded long-term success of trabeculectomy had improved. However, there were higher bleb-related complications with the use of MMC. Ologen is a new collagen matrix implant that is used for wound modulation following filtration surgery. It is an artificial porcine extracellular matrix which is made of atelocollagen cross-linked with glycosaminoglycan. Ologen is a biodegradable scaffolding matrix that induces a regenerative wound healing process without the need for adjunctive antifibrotics. It is specifically configured to prevent episcleral fibrosis and subconjunctival scarring. The implant is designed to decrease the random growth of fibroblasts and instead help in promoting their growth through the pores found in the Ologen implant itself.