Comparative Study of the Effect of Allium Sativum (Garlic), Allium Cepa (Onion) & Insulin on the Lingual Papillae of Streptozotocin Induced Diabetic Albino Rats

Abstract

Diabetes mellitus (DM) is a growing public health concern and a common chronic metabolic disease worldwide. Various inflammatory diseases and soft tissue pathologies in oral cavities are associated with DM. The major concern in diabetes is increased oxidative stress. Therefore, dietary supplementation with antioxidants such as vitamins, and flavonoids has been used in attempts to prevent the occurrence of many diabetes complications. Since onion & garlic are strong antioxidants & free radical scavengers and diabetes on the other hand, produce oxygen free radicals, so this study is carried out to determine their possible effect in minimizing complications that diabetic patients could suffer in comparison with insulin . Aim of the study: To assess the possible effect of onion & garlic in comparison with insulin in reducing the complications of DM through histological examination of tongue papillae. Materials and methods: Fifty albino rats, 10 diabetes free and 40 STZ induced diabetic: were divided into 5 groups, ten rats each. Control group, untreated diabetic group, insulin treated group, garlic treated group and onion treated group. Tongue specimens were sectioned, prepared and examined by H&E and SEM. Results: Most of filiform papillae appeared shortened with rounded