GESTATIONAL TROPHOBLASTIC DISEASE A HISTOPATHOLOGICAL AND ELECTRON MICROSCOPIC STUDY

Abstract

The present study was performed on 150 cases of GTD collected frm Department of Pathology, Tanta University as well as from pnvate labs, clini cs and hospitals of Gynecology & Obstetric from January 1994 to December 1998.

Ti ssue were fixed in neutral buffered formalin (I0%) for 24 hours, then paraffin embedded sections (3-5J..l) were prepared for stud y. The sections were subjected to routine haematoxylin and eosin study.

For electron microscopic study, two cases were obtained as fresh specimens and fixed in (2.5%) glutaraldehyde solution.

The 150 cases were di vided as 133 cases of hydatidiform mole, 12 cases of invasive mole, 3 cases of choriocarcinoma and 2 cases of placental site trophobl astic tumor. The 133 cases of hydatidiform mole were further subdivided into 97 cases of complete hydatidiform mole and 36 cases of partial hydatidiform mole. -

Hydatidiform mole (HM):

As regards the mean age among cases of CHM was 35 years old while it was sli ghtl y l ower for cases of PHM (30 years) Enlarged u terine s i ze occurred in all cases of CHM whi l e in PHM the uterus was of normal size for gestational age in most of the cases (91.6%) and small for gestational age in few cases (8.3%). Abnormal uterine bleeding was the co mmonest presenting symptom among HM cases whether complete or partial representing 98% and 96% respectively.