Difference between Oral Isosorbide Mononitrate & Sildenafil Citrate Therapy in Reducing Umbilical Artery Doppler Indices in Pregnancies with IUGR;

Abstract

SUMMARY ntrauterine growth restriction (IUGR) is an important cause of perinatal morbidity and mortality. The accurate assessment of fetal growth during pregnancy is difficult, but recent advances have improved this important aspect of obstetric care with positive implications for antenatal patients and their babies. The term IUGR defines an infant that has failed to achieve a weight threshold (usually defined as the 10th percentile). Normal fetal growth is dependent on intrinsic (genetic) and extrinsic (placental and maternal) factors. A failure of any or a combination of these factors will impair growth in affected fetuses. The identification of the specific cause of IUGR prior to delivery is essential because clinical management, parental counselling and pregnancy outcome are linked to the etiology. To achieve optimal fetal growth, adequate blood flow in utero-placental vascular unit is essential. Abnormal vasculature adaptation, result