Correlation between Serum Surfactant Protein D Level, Chest Radiologic Changes (HRCT) and Respiratory Functions Abnormalities in Patients with SCD

Abstract

ickle cell disease (SCD) is one of the most common severe monogenic disorders in the world. Hemoglobin polymerisation, leading to erythrocyte rigidity and vaso-occlusion, is central to the pathophysiology of this disease, although the importance of chronic anemia, hemolysis, and vasculopathy has been established. SCD patients may experience a variety of clinical complications attributed to anemia, hemolysis, and iron overload. Acute and chronic pulmonary complications of sickle cell anemia are common but often underappreciated by healthcare providers. These conditions have clearly emerged as major threats to the well-being and longevity of patients with sickle cell disease. In adult SCD patients, restrictive pattern in pulmonary function test (PFT) has been reported. Children with sickle cell disease have a significantly sharper decline in lung function with age when compared to other children of the same race and age. However, PFT in children with SCD has shown conflicting evidences ranging from normal, obstructive and restrictive pattern of PFT. Therefore, we evaluated pulmonary function test in children and adolescents with SCD and assessed its possible relation to clinical characteristics, markers of hemolysis and iron overload.