Assessment Of Nutritional Status In Egyptian Patients Undergoing Allogeneic Haematopoietic Stem Cell Transplantation

Abstract

HSC transplant patients are likely to develop a series of metabolic disorders of varying severity, mostly during the immediate post-transplant period. The main causes are the adverse effects of the conditioning regimen itself, the immunosuppressive drugs (to control or for prophylaxis of GVHD) and the total parenteral nutrition (TPN), which may increase the risk of opportunistic infections and inflammatory processes. The aim of this study was to Assess nutritional status in patient undergoing Allogeneic Haematopoietic Stem Cell Transplantation to decrease morbidity and mortality rate and improve quality of life. The study was conducted on 50 patients who had allogeneic HSCT at Ain Shams bone marrow transplantation unit. Results were as follow : There was significant difference in BMI at day 30 and day 180 in comparison to baseline,( p value <0.001). In contrast there was insignificant difference in BMI at day 180 in comparison to day 30,(p value = 0.075). There was significant difference in laboratory variables (sodium ,potassium, magnesium , phosphate , calcium , albumin , and hemoglobin at baseline , day 30 and day180 range (<0.001 and 0.002 respectively). in contrast , there was insignificant difference in total protein (p value = 0.252). Significant univariate analysis for global SGA at day 30 was comorbidity ,(p value <0.001),fever duration more than 1 week,( p value = 0.004), and fungal infection more than 1 week ,( p value = 0.045). Also , there was significant univariate analysis for global SGA at day 180 was comorbidity ,( p value = 0.001), diagnosis ,(p value = 0.023) ,fungal infection more than 1week ,( p value = 0.025) and ≥ grade II acute GI GVHD ,( p value <0.001). Significant multivariate analysis for global SGA at day 30 was comorbidity ,( p value = 0.002), and fever duration more than 1 week ,( p value = 0.012).Also there was significant multivariate analysis for global SGA at day 180 was comorbidity ,( p value= 0. 044), diagnosis ,( p value =0.036 ), and ≥ grade II acute GI GVHD ,(p value = 0.010).