PROSTAGLANDINS In obstetric and gynecological practice

Abstract

Prostaglandins derivatives found in involved in most inflammations.

SUMMARY

are naturally occurring fatty-acid almost all tissues in the human body and types of biological processes and

Changes in prostaglandin biosynthesis, metabolism and expression of various receptors play an important role in the pathophysiology of certain diseases including pre-term labor and pre-eclampsia. Moreover, inhibition of their biosynthesis by NSAIDs reflects a wide range of clinical applications including treatment of dysmenorrhea, menorrhagia, symptomatic polyhydramnios and prevention of pre-term labor and pre-eclampsia.

Synthetic prostaglandins and their analogs have been developed with the aim of obtaining compounds, which are more stable and have more specific effects and longer duration of action, are now widely used in clinical practice particularly in obstetrics and gynecology.