Radiation Induced Impairment of Certain Metabolic Levels in Albino Rat and Possible Control by Drugs Treatment
Ola Aly Gharib El-Deshw;
Abstract
This study was designed to evaluate the effect of silymarin as a hepatoprotective drug on the y- irradiation induced hazards on certain biological functions in rats.
This investigation was conducted through analyses of
certain biochemical parameters including determination of serum enzymes (AP, AST, ALT and GGTP) as well as serum cholesterol, triglycerides, urea and creatinine levels. Moreover, liver GSH content and GR and GSH-PX activities were estimated.
The results of this study showed that administration of
silymarin alone did not induce significant change in any of the parameters tested in case of serum GGTP activity and urea level, where a significant decrease of their levels was recorded and a significant increase of liver GSH content occurred. Whole body y irradiation revealed an increase in serum AP activity as well as in
liver GR and GSH- PX activities on the 151 post exposure day as
compared with control values. However, 3 days after radiation exposure these parameters showed a significant decrease below the control level and persisted till the end of the experimental time
except for serum AP activity that showed an increase on the ih
post exposure day of 3 Gy dose of irradiated treated rats. A gradual increase of serum ALT, AST, GGTP activities, triglycerides content and urea concentration were observed due to irradiation throughout the experimental time. Also, irradiation caused an initial increase of total serum cholesterol followed by a progressive declining. However, serum creatinine and liver GSH content showed an initial decrease, which continued till the end of experimental time as in case of liver GSH contents or followed by a progressive increase as in serum creatinine level.
However, a remarkable restoration of the enzyme activities was observed due to treatment with silymarin either before or after irradiation. This restoration assesses the protective and ameliorative effects of silymarin, which was higher in groups treated with single oral dose of silymarin than those treated with cumulative oral dose.
This investigation was conducted through analyses of
certain biochemical parameters including determination of serum enzymes (AP, AST, ALT and GGTP) as well as serum cholesterol, triglycerides, urea and creatinine levels. Moreover, liver GSH content and GR and GSH-PX activities were estimated.
The results of this study showed that administration of
silymarin alone did not induce significant change in any of the parameters tested in case of serum GGTP activity and urea level, where a significant decrease of their levels was recorded and a significant increase of liver GSH content occurred. Whole body y irradiation revealed an increase in serum AP activity as well as in
liver GR and GSH- PX activities on the 151 post exposure day as
compared with control values. However, 3 days after radiation exposure these parameters showed a significant decrease below the control level and persisted till the end of the experimental time
except for serum AP activity that showed an increase on the ih
post exposure day of 3 Gy dose of irradiated treated rats. A gradual increase of serum ALT, AST, GGTP activities, triglycerides content and urea concentration were observed due to irradiation throughout the experimental time. Also, irradiation caused an initial increase of total serum cholesterol followed by a progressive declining. However, serum creatinine and liver GSH content showed an initial decrease, which continued till the end of experimental time as in case of liver GSH contents or followed by a progressive increase as in serum creatinine level.
However, a remarkable restoration of the enzyme activities was observed due to treatment with silymarin either before or after irradiation. This restoration assesses the protective and ameliorative effects of silymarin, which was higher in groups treated with single oral dose of silymarin than those treated with cumulative oral dose.
Other data
| Title | Radiation Induced Impairment of Certain Metabolic Levels in Albino Rat and Possible Control by Drugs Treatment | Other Titles | الأختلالات التي تنشأ عن الإشعاع في بعض المستويات الأيضية في الجرذ الأبيض و إمكانية السيطرة عليها بالمعالجة بالعقاقير الدوائية | Authors | Ola Aly Gharib El-Deshw | Keywords | .Silymarin, Gamma radiation, Liver Functions, Cholesterol, Triglycerides, Creatinine, Urea, Hepatoprotective drug, Antioxidant enzymes and GSH content | Issue Date | 2001 |
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