Diffusion Weighted Magnetic Resonance Imaging to Monitor Treatment Response in Head and Neck Squamous Cell Carcinoma
Wessam Sherin Shokry;
Abstract
Head and Neck squamous cell carcinoma is the sixth most common cancer worldwide. (Kamangar et al., 2006).
Nowadays, non surgical therapy is the standard management aiming to preserve organ functions while maintaining the same survival rate.Chemoradiotherapy is increasingly chosen as the primary option to preserve the patient quality of life. .(Pazdur et al.,2009)
Several imaging modalities have been proposed for monitoring treatment response to chemoradiation and surgery. One of them is DWI which is of value as an early non invasive and clinically applicable method. (Koh et al., 2007)
Twenty five patients suffering from head and neck squamous cell carcinoma in different regions were chosen for the present work. Patients were referred from oncology department of Ain Shams university hospitals . The patients were evaluated before treatment and 4 to 6 weeks after the end of treatment. The duration of the treatment course was from 6 to 8 weeks. Therefore the response was evaluated three months after the beginning of treatment.
The response to chemoradiotherapy was evaluated by the apparent diffusion coefficient (ADC) before and after treatment. The ADC value was correlated with the different types of response according to RECIST criteria.
It was found that the tumor which respond positively after treatment revealed a significant increase in ADC value. This increase was concomitant with the clinical improvement of the patient and the regressed size of the tumor.
It was also found that the decrease in the ADC signals after treatment denoted progression of the malignancy in the patients. The present results were discussed and confronted with those of previous investigators.
Nowadays, non surgical therapy is the standard management aiming to preserve organ functions while maintaining the same survival rate.Chemoradiotherapy is increasingly chosen as the primary option to preserve the patient quality of life. .(Pazdur et al.,2009)
Several imaging modalities have been proposed for monitoring treatment response to chemoradiation and surgery. One of them is DWI which is of value as an early non invasive and clinically applicable method. (Koh et al., 2007)
Twenty five patients suffering from head and neck squamous cell carcinoma in different regions were chosen for the present work. Patients were referred from oncology department of Ain Shams university hospitals . The patients were evaluated before treatment and 4 to 6 weeks after the end of treatment. The duration of the treatment course was from 6 to 8 weeks. Therefore the response was evaluated three months after the beginning of treatment.
The response to chemoradiotherapy was evaluated by the apparent diffusion coefficient (ADC) before and after treatment. The ADC value was correlated with the different types of response according to RECIST criteria.
It was found that the tumor which respond positively after treatment revealed a significant increase in ADC value. This increase was concomitant with the clinical improvement of the patient and the regressed size of the tumor.
It was also found that the decrease in the ADC signals after treatment denoted progression of the malignancy in the patients. The present results were discussed and confronted with those of previous investigators.
Other data
| Title | Diffusion Weighted Magnetic Resonance Imaging to Monitor Treatment Response in Head and Neck Squamous Cell Carcinoma | Other Titles | دور التصوير بالرنين المغناطيسى باستخدام التشبع لمراقبة الاستجابة للعلاج في سرطان الخلايا الحرشفية في الرأس والرقبة | Authors | Wessam Sherin Shokry | Issue Date | 2015 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.