Association between Adiponectin and Diabetic Retinopathy and Nephropathy
Shaimaa Mohamed Kamel Ashery;
Abstract
This study aimed to elucidate the role of adiponectin in mixed
condition of microvascular complication of type 2 diabetes mellitus, in
particular retinopathy and nephropathy. In addition, we attempted to
correlate the serum levels of adiponectin with different parameters such as
glycemic state, insulin resistance, lipid profile and albumin-creatinine ratio
in type 2 diabetic patients with retinopathy and nephropathy in order to
determine the risk factors of this disease.
This study involved sixty diabetic patients with type 2 diabetes
mellitus with or without microvascular complications involving either
retinal, renal vasculatures or both and fifteen healthy subjects were involved
and served as Reference group.
Serum levels of adiponectin, routine diabetic diagnostic markers
including blood glucose levels, glycosylated hemoglobin, insulin resistance,
lipid profile, kidney function tests performed to all individuals included in
the study.
Full ophthalmological and clinical examinations (blood pressure,
search for lower limb oedema, pallor, renal mass, etc.) have done for each
subject.
Our data revealed that the levels of serum adiponectin were
decreased in patients with diabetic retinopathy while they were increased in
patients with either diabetic nephropathy or, to lesser extents, in diabetic
patients with renal and retinal involvements (nephropathy and retinopathy).
Serum adiponectin levels were found to correlate with some
parameters of lipid profile in patients with mixed conditions, a notion that
highlight the role of adiponectin in the pathogenesis of microvascular
complications of diabetes. Moreover, these results suggest that increased
total serum adiponectin may predict coexticency vascular endothelial
dysfunction in diabetic nephropathy patients. The findings of the present
study also suggest that adiponectin may be considered as prognostic marker
for of diabetic complications which will initiate a new era for the
management of diabetes
condition of microvascular complication of type 2 diabetes mellitus, in
particular retinopathy and nephropathy. In addition, we attempted to
correlate the serum levels of adiponectin with different parameters such as
glycemic state, insulin resistance, lipid profile and albumin-creatinine ratio
in type 2 diabetic patients with retinopathy and nephropathy in order to
determine the risk factors of this disease.
This study involved sixty diabetic patients with type 2 diabetes
mellitus with or without microvascular complications involving either
retinal, renal vasculatures or both and fifteen healthy subjects were involved
and served as Reference group.
Serum levels of adiponectin, routine diabetic diagnostic markers
including blood glucose levels, glycosylated hemoglobin, insulin resistance,
lipid profile, kidney function tests performed to all individuals included in
the study.
Full ophthalmological and clinical examinations (blood pressure,
search for lower limb oedema, pallor, renal mass, etc.) have done for each
subject.
Our data revealed that the levels of serum adiponectin were
decreased in patients with diabetic retinopathy while they were increased in
patients with either diabetic nephropathy or, to lesser extents, in diabetic
patients with renal and retinal involvements (nephropathy and retinopathy).
Serum adiponectin levels were found to correlate with some
parameters of lipid profile in patients with mixed conditions, a notion that
highlight the role of adiponectin in the pathogenesis of microvascular
complications of diabetes. Moreover, these results suggest that increased
total serum adiponectin may predict coexticency vascular endothelial
dysfunction in diabetic nephropathy patients. The findings of the present
study also suggest that adiponectin may be considered as prognostic marker
for of diabetic complications which will initiate a new era for the
management of diabetes
Other data
| Title | Association between Adiponectin and Diabetic Retinopathy and Nephropathy | Other Titles | الارتباط بين الاديبونكتين والاعتلال الشبكى والكلوى السكرى | Authors | Shaimaa Mohamed Kamel Ashery | Issue Date | 2015 |
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