MR Enterography in the Management of Patients with Crohn’sDisease
Nora Nabil Abdou Ahmed Mikawy;
Abstract
Crohn’s disease (CD) is a chronic IBD with an unpredictable course characterized by frequent flare-ups interspersed with periods of remission of varying length.
CD has a worldwide distribution but is more prevalent in Europe and North America .Prevalence in many developed countries is estimated at0.1%. In Egypt there is marked increase in the frequency of diagnosis of both UC and CD in the last 10 years.
The peak incidence of CD is in adolescents and young adults between15 and 25 years old; a second shallow peak is seen in the 50- 8 years old age group. It affects any part of the GIT from mouth to anus with 80% small bowel involvement, most commonly the terminal ileum, with characteristic multiple discontinuous sites involvement (skip lesions) and transmural inflammation.
Disease is distributed equally between the sexes, although isolated colonicdisease is more common in women than men.
CD is characterized by cumulative structural damage to the bowel with a progression from inflammation to penetrating disease and fibrosis over time. Medical treatment options are available, and the challenge is to identify patterns of disease behavior early to tailor treatment, identify complications, and use surgical options appropriately.
Although various imaging modalities are available, MRI is nowadays a leading methodology for assessing small bowel pathology. It is characterized by lack of radiation exposure combined with super soft tissue
Contrast, multiplaner capabilities and provision of functional information . Adequate distension of small bowel is the single most important prerequisite for individual lesion detection. Homogenous opacification of the bowel lumen, use of biphasic intra luminal contrast agents, application
Summary and conclusions
CD has a worldwide distribution but is more prevalent in Europe and North America .Prevalence in many developed countries is estimated at0.1%. In Egypt there is marked increase in the frequency of diagnosis of both UC and CD in the last 10 years.
The peak incidence of CD is in adolescents and young adults between15 and 25 years old; a second shallow peak is seen in the 50- 8 years old age group. It affects any part of the GIT from mouth to anus with 80% small bowel involvement, most commonly the terminal ileum, with characteristic multiple discontinuous sites involvement (skip lesions) and transmural inflammation.
Disease is distributed equally between the sexes, although isolated colonicdisease is more common in women than men.
CD is characterized by cumulative structural damage to the bowel with a progression from inflammation to penetrating disease and fibrosis over time. Medical treatment options are available, and the challenge is to identify patterns of disease behavior early to tailor treatment, identify complications, and use surgical options appropriately.
Although various imaging modalities are available, MRI is nowadays a leading methodology for assessing small bowel pathology. It is characterized by lack of radiation exposure combined with super soft tissue
Contrast, multiplaner capabilities and provision of functional information . Adequate distension of small bowel is the single most important prerequisite for individual lesion detection. Homogenous opacification of the bowel lumen, use of biphasic intra luminal contrast agents, application
Summary and conclusions
Other data
| Title | MR Enterography in the Management of Patients with Crohn’sDisease | Other Titles | دور الاشعة بلرنين المغناطيس فى تشخيص النهاب الامعاء الدقيقة المعروف بمرض كرونز | Authors | Nora Nabil Abdou Ahmed Mikawy | Issue Date | 2015 |
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