A STUDY OF THE EFFECTS OF ORAL THEOPHYLLINE SR, INHALED SALMETEROL AND INHALED CORTICOSTEROID ON BRONCHIAL HYPERRESPONSIVENESS IN ATOPIC ASTHMA

Abstract

The aim of this work was to study the effect of oral theophylline (SR) , inhaled salmeterol and inhaled beclomethasone dipropionate on bronchial hyperresponsiveness in mild atopic asthmatic patients, the work was conducted on 30 patients, they were classified into 3 groups. Group I : included 10 patients , they were 7 males and 3

females with a mean age of 27 years (range 22-40 years) they received oral theophylline (SR) 200 mg /12 hours for 4 weeks

Group II : included 10 patients, they were 6 males and 4 females with a mean age of 25 years (range 20-38 years)they received inhaled salmeterol 50 11g I 12 hours for 4 weeks

Group III : included 10 patients, they were 6 males and 4 females with a mean age of 26 years (range 20-38 years)they received inhaled BDP 200 ug I 6 hours for 4 weeks.

All patients fulfilled the American Thoracic Society criteria of asthma, they had baseline FEV 1o/o less than 70o/o and FEV 1 more than 70o/o of predicted. They showed improvement in FEV 1 (o/o of predicted) more than 20o/o on administration of two puffs of salbutamol.