Ameliorative Effect of some Nuts against Ethanol induced Pancreatic Injury in Rats

Abstract

The aim of the present study was to assess the ameliorative effects of dietary supplementation with peanut, pistachio or cashew nuts (1g %) on the complications associated with ethanol induced pancreatic injury in rats. Forty male albino rats were divided into 5 groups. Group (1): rats were fed on standard diet for 8 weeks (control) , group (2): rats were fed on standard diet for 8 weeks and received ethanol in drinking water (15% v/v) ad libitum at the first 4 weeks, groups (3, 4 and 5): rats were fed on standard diet and received ethanol in drinking water (15% v/v) ad libitum for 4 weeks then fed on the diet supplemented with (1%) of grounded peanut, pistachio and cashew, respectively for another 4 weeks. The results showed that pretreatment of ethanol caused disturbance in glucose homeostasis, pancreatic enzymes secretion, antioxidant status and lipid profile, while the tested nuts produced significant ameliorative effects.