Evaluation of hepatorenal protective activity of Moringa oleifera on histological and biochemical parameters in cadmium intoxicated rats

Abstract

This study was carried out to clarify the effect of herbal drug (Moringa oleifera, Mo) administration on hepatorenal intoxication by cadmium (Cd). Experiment I, (15 adult male rats) for induction of Cd toxicity where rats were administrated 1 mg/kg cadmium chloride for 4 weeks. Experiment II (15 adult male rats) included the following groups: Group 1 (control group). Group 2 (Mo) rats treated with 400 mg/kg Moringa and Group 3 (Cdþ Mo) rats treated with Mo after Cd toxicity. The results showed that Cd treatment caused significant elevations in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, and hepatic tissue malondialdehyde (MDA). While a decrease in the hepatic tissue superoxide dismutase (SOD) and reduced glutathione (GSH) levels were observed. Furthermore, Cd-induced congestions, necrosis, mononuclear-cell infiltrations, and dilatation of renal tubules and hepatic sinusoids in the kidney and liver tissues. Also, there was a substantial deposition of collagenous fibers in the renal capsule and around the portal area. The animals were treated with Moringa after Cd intoxication showed a distinctive improvement in the biochemical parameters, histological and histochemical pictures of the hepatic and renal tissues.