Propargylation of Ugi Amide Dianion: An Entry into Pyrrolidinone and Benzoindolizidine Alkaloid Analogues
Ali, Ali Khalil; Cordier, Marie; El-Naggar, Abeer M.; Abd El-Sattar, Nour E. A.; Hassan, Mohamed Ali; Zidan, Alaa; El Kaïm, Laurent;
Abstract
Copyright © 2018 American Chemical Society. Propargylation of Ugi adducts under the addition of excess sodium hydride in DMSO leads to direct formation of pyrrolidinone enamides, which are useful precursors of iminium intermediates and may be trapped by various nucleophiles. This approach has been applied to the formation of benzoindolizidine alkaloids with high diversity via a Ugi/propargylation/Pictet-Spengler cyclization.
Other data
| Title | Propargylation of Ugi Amide Dianion: An Entry into Pyrrolidinone and Benzoindolizidine Alkaloid Analogues | Authors | Ali, Ali Khalil ; Cordier, Marie ; El-Naggar, Abeer M. ; Abd El-Sattar, Nour E. A. ; Hassan, Mohamed Ali ; Zidan, Alaa ; El Kaïm, Laurent | Issue Date | 2018 | Publisher | American Chemical Society | Journal | Organic Letters | DOI | 9 2568 https://api.elsevier.com/content/abstract/scopus_id/85046622372 20 1523-7052 10.1021/acs.orglett.8b00687 |
PubMed ID | 29683331 | Scopus ID | 2-s2.0-85046622372 |
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