Evaluation of serum interleukin-6 levels and lipid profile as biomarkers in egyptian patients with atherosclerotic coronary artery disease

Abstract

© 2015 AENSI Publisher All rights reserved. Background: Inflammatory processes are now recognized to play a central role in the pathogenesis of atherosclerosis and its complications. Plasma levels of several markers of inflammation have been found to be associated with future cardiovascular risk in a variety of clinical settings. Vascular lipid accumulation and inflammation are hallmarks of atherosclerosis and perpetuate atherosclerotic plaque development. Mediators of inflammation such as interleukin-6 [IL]-6, are related to the arterial wall inflammatory process and may contribute to the pathogenesis of atherosclerosis. Objective: To assess the association of serum interleukin-6 [IL-6] with atherosclerosis and risk factors such as diabetes, hypertension, dyslipidemia, and obesity in Egyptian patients. Subjects: A total of 120 Egyptian Subjects [60 patients with CAD and 60 patients without CAD] were included in the study besides age - sex matched 50 healthy controls were taken for comparison. Methods: Lipid profiles [total cholesterol, triglyceride, HDL-C] were measured by enzymatic colorimetric method and serum IL-6 levels were determined using ELISA. Results: Our data revealed a significant association between serum IL-6 level and lipid profiles [total cholesterol, triglyceride, HDL-C and LDL-C] and elevation of serum IL-6 level was observed in atherosclerotic patients compared with healthy subjects. Conclusion: The present study showing a strong association between IL-6 and dyslipidemia as an important risk factor of atherosclerosis and a markedly high level of IL-6 in Patients with atherosclerosis, based on which suggests that IL-6 may be served as an early and susceptibility biomarker in the pathogenesis of atherosclerosis.