Placental protein 13, galectin 14 and pentraxin 3 for prediction of preeclampsia in Egyptian patients

Abstract

Background: Pre-eclampsia (PE) is considered one of the most dangerous pregnancy complications, and the leading cause of maternal and perinatal mortality and morbidity. Objective: The aim of the current study was to evaluate two galectins (GAL) and some biochemical parameters in the diagnosis of PE. Materials and Methods: The study included a total of 96 women, including 66 pregnant women with PE, and 30 normotensive pregnant females. The biomarkers studied, at the 3 trimesters, included GAL13 and 14, pentraxin 3 (PTX3), C-reactive protein (CRP), liver function tests, and lipid profile. Results: Results indicated that a significant difference in GAL13 and 14 and PTX3 in preeclamptic women compared to normotensive pregnant ones. The level of CRP showed non-significant change in all patient’s groups. Liver function tests, total cholesterol, low-density lipoprotein cholesterol, and triacylglycerols revealed a high significant increase in all patient’s groups. Levels of high-density lipoprotein cholesterol were highly significant decreased in 2nd and 3rd-trimester patients. Conclusion: The specificity and sensitivity of GAL14 provided the highest diagnostic information of these biomarkers and are in close to GAL13 and PTX3; while, CRP yielded a significantly worse accuracy for diagnosing PE.