Fetotoxicity of 2,4-dichlorophenoxyacetic acid in rats and the protective role of vitamin E
Fatma M Mazhar; Karima M Moawad; Mai H El-Dakdoky; Samir, Amany;
Abstract
The present study was conducted to investigate the potential role of 2,4-dichlorophenoxyacetic acid (2,4-D) in
inducing developmental toxicity and oxidative damage in pregnant rats and their fetuses as well as to assess the
efficacy of vitamin E to prevent or alleviate such defects. Pregnant rats received 2,4-D (100 mg/kg bw) alone or
in combination with vitamin E (100 mg/kg bw) daily from gestation day 1 to 19. The number of implantations,
viable and resorbed fetuses and sex ratio were not statistically different among groups. However, fetuses
maternally treated with 2,4-D were characterized by lower body weight and higher morphologic and skeletal
defect rate. 2,4-D induced oxidative stress in the liver of mothers and fetuses which was indicated by a significant
elevation of malondialdehyde level with reduction in catalase activity and total antioxidant capacity. Coadministration
of vitamin E can counteract the deleterious effects of 2,4-D by successive reduction in the
oxidative stress.
inducing developmental toxicity and oxidative damage in pregnant rats and their fetuses as well as to assess the
efficacy of vitamin E to prevent or alleviate such defects. Pregnant rats received 2,4-D (100 mg/kg bw) alone or
in combination with vitamin E (100 mg/kg bw) daily from gestation day 1 to 19. The number of implantations,
viable and resorbed fetuses and sex ratio were not statistically different among groups. However, fetuses
maternally treated with 2,4-D were characterized by lower body weight and higher morphologic and skeletal
defect rate. 2,4-D induced oxidative stress in the liver of mothers and fetuses which was indicated by a significant
elevation of malondialdehyde level with reduction in catalase activity and total antioxidant capacity. Coadministration
of vitamin E can counteract the deleterious effects of 2,4-D by successive reduction in the
oxidative stress.
Other data
| Title | Fetotoxicity of 2,4-dichlorophenoxyacetic acid in rats and the protective role of vitamin E | Authors | Fatma M Mazhar ; Karima M Moawad ; Mai H El-Dakdoky ; Samir, Amany | Keywords | 2,4-dichlorophenoxyacetic acid, fetotoxicity, oxidative stress, pregnant rats, skeletal abnormalities, vitamin E | Issue Date | Jun-2014 | Publisher | Toxicology and Industrial Health | DOI | 10.1177/0748233712459915 |
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