QUALITY CONTROL MONITORING OF RED BLOOD CELL CONCENTRATES DURING STORAGE IN BLOOD BANKS

Abstract

uring storage, RBCs undergo various metabolic, structural and morphological changes, the so-called storage lesions. The acceptable extent of the metabolic changes forms a major part of the blood bank quality guidelines. PRBCs are widely used for the treatment of patients with anemia of different etiologies. For this purpose it is important that the transfused RBCs preserve their metabolic capacity and mechanical functions. It is therefore very important to control the quality of PRBC units. The method by which blood products are produced, the storage solution used, and other factors as prestorage leukoreduction have an effect on the final product and may influence quality. Product standardization is thus a challenge facing all blood biologic manufacturers The current study was carried out on 20 PRBC units at 4 testing time points (D1, 10, 20 and 35) to evaluate the effect of storage on PRBCs. We measured various biochemical parameters ( Plasma Na+, K+, ATP , 2,3 DPG and blood gases) and other hematological parameters (WBCs, Hb, Hct, % hemolysis, RBC indices and abnormal cells %) in rder to assess the quality of these units according to the regulatory standards.