CYANOBACTERIA AS BIOPRODUCERS OF ECONOMIC COMPOUNDS
BASSANT ESSAM AHMED SAYED;
Abstract
Cyanobacteria are known as a potential source of several metabolic compounds like phytohormons, phenols, amino acids, fatty acids, alkans as well as pharmaceuticals. These compounds are reported to be used in agriculture, biology and medicine. This study was performed to isolate Anabeana, Nostoc and Fischerella sp, from river Nile, Egypt. Also, their potential to produce some bioactive compounds were evaluated.
Results indicated that Fischerella BS1-EGisolated during this study
as well as other Anabeana and Nostoc isolates have a considerable antifungal activity against Aspergillus,Fusarium and Penicillum sp. In general, the determined fungal activities by means of inhibition zone ranged from6.8-16mm.
Regarding the cell cytotoxicity of Anabaena, Nostoc and Fischerella BS1-EG cultures on liver cancer (HepG-2), lung cancer (A549), colon cancer (HCT-116), breast cancer (MCF-7), data indicated that all cyanobacterial crude extracts exhibited a variable influence on all tested cell lines. GC-MS analysis showed that 31 different compounds were detected and identified as fatty acids, alkaloids, phenols, amino acids. The most important 14 compounds were identified as anticancer, antimicrobial, antiinflammatory agents. Also 26 different compounds and the most important 15 compounds from Anabeana Qr and 22 compounds from Nostoc Sh1 and the most important 9 compounds having different biological activites.
On the other hand, results revealed that all tested cyanobacterial cultures proved to have anti hyper glycemia activity through inhibition of α-glucosidase activity. These results may indicate that, for the first time, Fischerella BS1-EG. is recorded to have different avenues as human anticancer and antidiabetic.
Keywords: Cyanobacteria, Fischerella , GC-MS, antidiabetic,
anticancer.
Results indicated that Fischerella BS1-EGisolated during this study
as well as other Anabeana and Nostoc isolates have a considerable antifungal activity against Aspergillus,Fusarium and Penicillum sp. In general, the determined fungal activities by means of inhibition zone ranged from6.8-16mm.
Regarding the cell cytotoxicity of Anabaena, Nostoc and Fischerella BS1-EG cultures on liver cancer (HepG-2), lung cancer (A549), colon cancer (HCT-116), breast cancer (MCF-7), data indicated that all cyanobacterial crude extracts exhibited a variable influence on all tested cell lines. GC-MS analysis showed that 31 different compounds were detected and identified as fatty acids, alkaloids, phenols, amino acids. The most important 14 compounds were identified as anticancer, antimicrobial, antiinflammatory agents. Also 26 different compounds and the most important 15 compounds from Anabeana Qr and 22 compounds from Nostoc Sh1 and the most important 9 compounds having different biological activites.
On the other hand, results revealed that all tested cyanobacterial cultures proved to have anti hyper glycemia activity through inhibition of α-glucosidase activity. These results may indicate that, for the first time, Fischerella BS1-EG. is recorded to have different avenues as human anticancer and antidiabetic.
Keywords: Cyanobacteria, Fischerella , GC-MS, antidiabetic,
anticancer.
Other data
| Title | CYANOBACTERIA AS BIOPRODUCERS OF ECONOMIC COMPOUNDS | Other Titles | السيانوبكتريا كمنتج حيوي للمواد ذات القيمة الاقتصادية | Authors | BASSANT ESSAM AHMED SAYED | Issue Date | 2018 |
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