Ultrastructural changes Of the liver in hepatitis C infection
Youmna Kamel Mohamed Abe-el Sadek;
Abstract
Viral hepatitis is a major cause of morbidity and mortality with an estimated 200 millions chronically infected individuals worldwide. Six major viruses are recognized till now as etiologic agents responsible for most clinical cases of viral hepatitis: hepa titis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), Hepatitis D virus (HDV), hepatitis E virus (HEV) and Hepatitis G virus (HGV) (Dusheiko, 1990 and Fried and Marin
1996). Hepatitis C infection may cause a benign, asymptomatic disorders with an indolent course but it may cause progressive liver disease, cirrhosis and liver cancer.
The nomenclature of chronic hepatitis has changed since the late 1960s(Brunt , 2000). Classification system of chronic hepatitis was first proposed in 1968, which recognized two major histologic patterns "chronic persistent hepatitis: and chronic aggressive hepatitis" (De Greoote et al ., 1968).
Several histologic classification systems have been propos ed to minimize these uncertainties and provide a uniform stand ard that can be used to compare histologic findings in clinical trials . Although Some of these classifications are qualitative ; quantitative system are most common frequently used in clinical trials since they are amenable to statistical analysis (Bonis et al.,1997). The most common quantitative system that has been used in the assessment of chronic viral hepatitis is the Knodell score (Knodell et al ., 1981).
In addition, another semiquantitative system, the Metavir score, has been increasingly used for chronic hepatic C
1996). Hepatitis C infection may cause a benign, asymptomatic disorders with an indolent course but it may cause progressive liver disease, cirrhosis and liver cancer.
The nomenclature of chronic hepatitis has changed since the late 1960s(Brunt , 2000). Classification system of chronic hepatitis was first proposed in 1968, which recognized two major histologic patterns "chronic persistent hepatitis: and chronic aggressive hepatitis" (De Greoote et al ., 1968).
Several histologic classification systems have been propos ed to minimize these uncertainties and provide a uniform stand ard that can be used to compare histologic findings in clinical trials . Although Some of these classifications are qualitative ; quantitative system are most common frequently used in clinical trials since they are amenable to statistical analysis (Bonis et al.,1997). The most common quantitative system that has been used in the assessment of chronic viral hepatitis is the Knodell score (Knodell et al ., 1981).
In addition, another semiquantitative system, the Metavir score, has been increasingly used for chronic hepatic C
Other data
| Title | Ultrastructural changes Of the liver in hepatitis C infection | Other Titles | التغيرات المتناهية الدقة فى الكبد للإلتهاب الفيروسى س | Authors | Youmna Kamel Mohamed Abe-el Sadek | Issue Date | 2002 |
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