Omentin-1 Level and Carotid Intimal Thickening in Patients with Fatty Liver Disease and Diabetes Type 2

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a well-established hepatic manifestation of the metabolic syndrome and is one of the most common causes of chronic liver disease (Jialal et al., 2013). Many reports have found that adipokines have a role in the pathogenesis of NAFLD and are linked to insulin resistance (Jialal et al., 2013). Diabetes mellitus is a very common metabolic disease occurs in different age groups. Its incidence is increasing in a rapid manner (Garber et al., 2017). Egypt is classified as one of the top 10 countries in diabetes prevalence among adults according to international diabetes federation statistics in 2006 (Danaei et al., 2011). Carotid intima-media thickness (IMT) and arterial stiffness are useful surrogate markers for subclinical atherosclerosis and are significantly correlated with various metabolic risk factors (Moreno-Navarrete et al., 2011). Obesity has so many complications including diabetes and cardiovascular diseases (Arendas et al., 2008). Multiple studies were performed to confirm the role of obesity in development of insulin resistance syndrome which leading to hyperinsulinemia, hypertension, dyslipidemia and type 2 diabetes mellitus (Boden et al., 2013). All the previously mentioned riskfactors are implicated in