Clinical Significance of Lymphoid Enhancer-Binding Factor 1 (LEF-1) Expression in Acute Myeloid Leukemia

Abstract

Lymphoid enhancer binding factor 1 is an important member of the LEF/ T-cell factor transcription factors family. It has an important role in cellular proliferation and cell cycle regulation. It is traditionally regarded as a central mediator of the Wnt/ β catenin signaling pathway. It has vital function in early hematopoiesis and leukemic transformation in murine models. Wnt signaling pathway has diverse and fundamental functions in physiological (such as embryogenesis, organogenesis, proliferation, tissue repair and cellular differentiation) and pathological (carcinogenesis, congenital/genetic diseases, and tissue degeneration) processes. Wnt signaling pathway aberrations are associated with both solid tumors and hematological malignancies