Assessment of Serum and Tissue Level of Interleukin 33 in Patients with Atopic Dermatitis

Abstract

SUMMARY A D is a common, complex and chronic inflammatory skin disorder characterized by eczema, pruritus and cutaneous hyper-reactivity to allergic, irritant or microbial triggers, and affected individuals suffer significant morbidity. The pathogenesis of AD is a product of complex interactions among susceptibility genes, the host's environments, defect in barrier function and systemic and local immunological response. IL-33/ST2 signaling has been studied in a wide range of inflammatory skin conditions for its crucial role in immune response and tissue homeostasis and it was found that IL-33 level increased in the skin and serum of patients with AD. In the present study, the possible role of IL-33 in the pathogenesis of AD was evaluated by measuring its level in both serum and tissue of AD patients and comparing it with IL-33 level in normal healthy subjects (controls).