Evaluation of Role of Beta 2 Microglobulin and P- ANCA in the diagnosis of Ulcerative Colitis and their Correlation to Disease Activity

Abstract

T he serologic panel for IBD is rapidly expanding. So far, antibodies against Saccharomyces cerevisiae (ASCA) and perinuclear antineutrophil cytoplasmic proteins (p-ANCA) have been used in diagnosis of IBD, to distinguish Crohn’s disease (CD) from ulcerative colitis, and to predict the risk of complications of CD (Lewis JD, 2011). For the inflammatory bowel disease, β2-M was suggested to be used as an activity parameter. B2-M serum levels as an index of T-lymphocytes and macrophages activation in IBD patients reflects the degree of activity and severity of the inflammatory response (Yilmaz B et al., 2014). As an inflammatory marker, B2-M has been investigated in patients with IBD in several studies. However, the results were conflicting and not all authors were able to confirm a correlation (Yilmaz B et al., 2014).