Follicular Output RaTe (FORT) may predict Intra Cytoplasmic Sperm Injection (ICSI) outcome

Abstract

The endocrinologists and gynecologists adevised various methods to assess the ovarian reservoir and the expected responsiveness. Antral follicle count (AFC) is one of the non- invasive methods used for the assessment of the sensitivity of antral follicles to FSH. AFC represents the number of remaining primordial pool which corresponds to the number of oocytes retrieved; however, it does not influence the number of oocytes, embryo quality and the outcome of ICSI. The number of pre-ovulatory follicle count (PFC) obtained at the end of COH is estimated to be the best indicator of the number of retrieved oocytes. However, antral follicle count also includes the number of small antral follicles available before treatment. It means that follicular output rate (FORT) determines follicular response to exogenous HMG by the ratio of pre-ovulatory follicles to the existing pool of small antral follicles. The index has been investigated as an indicator of existing ovarian reservoir in response to stimulation and oocyte. From the previous researches through this study; It seems that FORT is a valuable qualitative indicator of ovarian follicles competence and may have a significant correlation with the outcome of the IVF/ICSI treatment technology.FORT is a predictor of oocyte competence in terms of a number of retrieved, mature and fertilized oocytes. The indicator can be used for prediction of clinical pregnancy rate after ICSI. It also gives information about the number of cleaved embryos and clinical pregnancy rate which needs to be further explored in large scale studieds.