Effect of atypical antipsychotics on serum BDNF levels in patients with schizophrenia

Abstract

Schizophrenia is a disorder of the executive function of both sensory and central nervous system (CNS). Although schizophrenia is characterized by a single disease, it is considered as a heterogeneous clinical syndrome affecting one’s thoughts, feeling and acts; the disease is secondary to a dysregulation of neurotrophic factor levels during brain development, which could lead to disorganization of neuronal networks. Inadequate neurotrophic support in the adult brain may decrease its capacity to adapt to changes and increase vulnerability to neurotoxic damage.