Correlation of Tumor Infiltrating CD4+ and CD8+ Lymphocytes and Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
Radwa Mohamed Hamed;
Abstract
ABSTRACT
A better understanding of tumor subtypes and molecular mechanisms of breast cancer is essential for development of innovative therapeutic strategies for modulation of the immune response.
The analysis of neoadjuvant treatment of breast cancer allows direct assessment of therapy response as well as its effect on disease-free survival and overall survival.
Tumor-infiltrating lymphocytes have been associated with higher rates of pathological complete response (pCR) to neoadjuvant therapy with improved prognosis in early and advanced stage TNBC and HER2-positive breast cancer.
The international immuno-oncology working group guidelines state that TILs should be assessed as a continuous variable to enable it to be implemented in algorithms encompassing other prognostic clinical-pathological variables.
A better understanding of tumor subtypes and molecular mechanisms of breast cancer is essential for development of innovative therapeutic strategies for modulation of the immune response.
The analysis of neoadjuvant treatment of breast cancer allows direct assessment of therapy response as well as its effect on disease-free survival and overall survival.
Tumor-infiltrating lymphocytes have been associated with higher rates of pathological complete response (pCR) to neoadjuvant therapy with improved prognosis in early and advanced stage TNBC and HER2-positive breast cancer.
The international immuno-oncology working group guidelines state that TILs should be assessed as a continuous variable to enable it to be implemented in algorithms encompassing other prognostic clinical-pathological variables.
Other data
| Title | Correlation of Tumor Infiltrating CD4+ and CD8+ Lymphocytes and Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer | Other Titles | العلاقه بين تواجد الخلايا الليمفاويه من نوع 4CD و 8CD والاستجابه للعلاج الكيماوي ما قبل الجراحه في اورام الثدي المتقدمه موضعياً | Authors | Radwa Mohamed Hamed | Issue Date | 2018 |
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