Flowcytometric And ISH Markers In Children With Acute Lymphoblastic Leukemia
Gehan EI-fhussiney Mohamed Gawish;
Abstract
ALL is the most common cancer occurring in children, representing
23% of cancer diagnoses among children younger than 15 years and occurring at an annual rate of approximately 30 to 40 per million. Flow cytometry is often used to examine the cells from bone marrow, lymph nodes, and blood samples. It is very accurate in determining the exact type of
leukemia.
The DNA content of the cell can provide a great deal of information about the cell cycle. The measurement of the DNA content of cells was one of the first major applications of flow cytometry and is still one of the biggest
• applications in this laboratory today.
Apoptosis {programmed cell death) is a physiologic phenomenon where in the dying cell plays an active part in its own destruction. Apoptosis plays a role in many diseases. There is a great potential for treatment of these diseases in developing agents that can alter the apoptotic process and change the natural disease progression. Molecules whose roles in apoptosis have been investigated include: Bcl-2 and c-myc proteins, the p53 tumor suppressor gene and various tumor suppressor gene products.
23% of cancer diagnoses among children younger than 15 years and occurring at an annual rate of approximately 30 to 40 per million. Flow cytometry is often used to examine the cells from bone marrow, lymph nodes, and blood samples. It is very accurate in determining the exact type of
leukemia.
The DNA content of the cell can provide a great deal of information about the cell cycle. The measurement of the DNA content of cells was one of the first major applications of flow cytometry and is still one of the biggest
• applications in this laboratory today.
Apoptosis {programmed cell death) is a physiologic phenomenon where in the dying cell plays an active part in its own destruction. Apoptosis plays a role in many diseases. There is a great potential for treatment of these diseases in developing agents that can alter the apoptotic process and change the natural disease progression. Molecules whose roles in apoptosis have been investigated include: Bcl-2 and c-myc proteins, the p53 tumor suppressor gene and various tumor suppressor gene products.
Other data
| Title | Flowcytometric And ISH Markers In Children With Acute Lymphoblastic Leukemia | Other Titles | تعيين بعض دلالات سرطان الدم الليمفاوى الحاد فى الاطفال باستخدام جهاز سريان الخلايا والتهجين الموضعى الفلوروسنس | Authors | Gehan EI-fhussiney Mohamed Gawish | Issue Date | 2007 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B12250.pdf | 896.88 kB | Adobe PDF | View/Open |
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