PHARMACOKINETICS. OF CIPROFLOXACIN IN NORMAL AND EXPERIMENTALLY INDUCED HEPATIC OR RENAL INSUFFICIENCY IN CHICKEN

Abstract

In the present work, the pharmacokinetic parameters following single intravenous and oral administration of 5 mg/ kg body weight ciprofloxacin in normal chicken were studied. Bioavailability percent in normal chicken was calculated. Disposition kinetic of ciprofloxacin following repeated oral administration of 5 mg/ kg body weight of ciprolloxacin once daily for five consecutive days, and also tissue residues 'were .determined in normal, hepatic insufficient and renal insufficient chicken. 7.1. Pharmacoldnetic studies ofciprofloxacin in normal chiclwn: Following a single intravenous injection of 5 mg/ kg body weight of ciprofloxacin in normal chicken, the drug could be detected therapeutically for 24 hours post injection with mean value of 0.022 11gl mi. The serum concentration-time curve following a single intravenous injection showed that the drug obeyed a three compartments open model. The disposition kinetics of ciprofloxacin following a single intravenous injection revealed a considerable rapid distribution phase (a) equal to 4.18 h- 1 with a distribution half-life (to.sa) equal to I .66 h. The volume of distribution of ciprofloxacin of the central compartment (V 1 ), first peripheral compartment (V2) and second peripheral compartment (V3) were 713.21, 2521.34 and 437.58 ml/ kg respectively. The apparent volume of distribution which was calculated by steady-state method (V dss) equal to 3672.13 ml/ kg. Ciprofloxacin was transfened from the central compartment to the first peripheral compartment at a faster rate (K 12) equal to 0.540 h- 1 than its passage from the first peripheral compartment to the central cori1partment (K21 ) equal to 0.153 lf 1 •