Neutrophil CD 11B, and Early Apoptosis of Neutrophil bAnnexin in Criticallilly Patients with Sepsis

Abstract

Sepsis remains a major problem and represents a major cause of death in the intensive care unites. Sepsis demonstrates a marked dysregulation of the immune system in its ability to maintain homeostasis in the face of infection by microorganism.

In multicellular organisms cellular homeostasis is maintained through a delicate balance between cell proliferation and cell death. Physiological cell death occurs through a process of cell suicide called apoptosis.

However, dysregulation of apoptosis of many cell types eg. Lymphocytes occurs in vivo in models of infection and can be one of the markers of sepsis.

Neutrophils represents one of the most important immunological parameter playing a role in the pathogensis of sepsis.

The integrin CD 11b is an important adhesion molecule mediating the transedothelial migration of circulating neutrophils into an inflammatory region.

The aim of the present work was to study the effect of sepsis on apoptosis of circulating neutrophils and adhesion molecule CD 11 b in critically ill pediatric patient.