Comparison between the effect of platelet rich plasma (PRP) and hyaluronic acid local injection in treatment of thumb carpometacarpal joint osteoarthritis

Abstract

Abstract Objectives: to compare the effectiveness of PRP versus hyaluronic acid injection in osteoarthritis of thumb carpometacarpal joint based on clinical and functional outcome measures. Patients and methods: Prospective interventional study conducted on thirty patients with thumb CMC OA. Patient was assessed by joint Palpation for tenderness with grading from I-IV, Provocative tests (Grind test and Lever test), VAS for pain, AUSCAN score, grip and pinch strength. The patients were randomly divided into two equal groups, Group 1: received Platelet-Rich Plasma (PRP) intra-articular injection. Group 2 received hyaluronic acid injection. Re-evaluation at 4 and 12 weeks was done for tenderness, VAS, AUSCAN index, Grip and pinch strength.