Production and Biochemical Studies on Thrombolytic Enzyme from some Indigenous Bacilli of Egyptian Environments.

Abstract

Formation of blood clots in the blood vessels, which leading to the condition called thrombosis, is the primary cause of death due to cardiovascular diseases in world-wide. Conventional thrombolytic agents such as streptokinase, tissue plasminogen activator, urokinase, have several limitation as higher cost of production as well as their side effects which forced the researchers to find alternative and safer fibrinolytic enzymes This work included the isolation of 126 strains of Bacillus spp. from different Governorates from Egyptian environment and they were screened for their ability to produce fibrinolytic enzyme and Bacillus isolate No.26 achieved the highest fibrinolytic enzyme activity using skimmed milk agar plate followed by fibrin agar plate through the qualitative studies.